The Importance of Interneurons in Neuronal Circuitry


The diversity of interneurons in the central nervous system is striking. Only in the cortex, interneurons account for around 20% of all neurons; most of these cells are GABAergic and are morphologically and functionally diverse since they comprise no less than twenty-three different types. Indeed, the malfunction of some of these neurons has been associated with some neurological disorders such as depression, epilepsy or schizophrenia.
In general, each interneuron type can be more effectively driven by a preferred stimulus; this diversity of activation thus broadens the operating range of the neuronal circuits. In this context, understanding the roles of each individual interneuron type is a critical first step in elucidating the functionality of the whole neuronal circuit.
This Research Topic will focus on how local interneurons modulate sensory signal processing and highlight the roles that interneurons play in physiological or pathological circuitries.

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